14^th International Conference on
Rheumatology and Arthroplasty

Biography:

Abstract:

Background: In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms and BMI has been investigated by a great number of studies. It has been hypothesized that VDR polymorphisms may influence the bone mass. However, studies investigating the associations between specific VDR polymorphisms and bone mass often show controversial results. We have now performed a systematic review of the literature to analyse the relevance of VDR polymorphisms for bone mass. Materials and Methods: An analysis of studies evaluating the association between vitamin D receptor gene polymorphisms Fok1, Bsm1, Taq1, Apa1, and Cdx2, poly (A) and Bgl1 as well as some haplotype combination has been performed. Data were extracted from PubMed using the key words VDR polymorphism in combination with bone mass. Results: This analysis was performed with the intent of giving an up-to-date overview of all data concerning the relevance of VDR polymorphisms for bone mass. Obviously, at present it is still not possible to make any definitive statements about the importance of the VDR genotype for bone mass. It seems probable that interactions with other factors such as calcium and vitamin D intake, 25(OH)D plasma levels and others gene play a decisive role in BMI occurrence and should not be underestimated. Other risk factors such as obesity, smoking status, alcool and others are also frequently mentioned as being more or less important for BMI depending on the VDR genotype. Conclusion: The determination of the VDR is hardly usable test from the point of view of clinical practice. The association between VDR and bone mass is relatively small overall. To date, however, the role played by the VDR gene polymorphisms on bone mass has not been defined with precision and requires a further confirmation in larger population groups, better characterized and different from ethnic point of view. Probably other and environmental factors involved in determining bone mass have yet to be identify.

Biography:

Specialist Physician in Physical Medicine, Rheumatology and Rehabilitation. · Born in Mosul/Iraq1955 . Elementary & Secondary school there 1974. · M.B.Ch.B.in 1980 from College of Medicine / University of Mosul . M.Sc.in Physical Medicine, Rheumatology and Rehabilitation in 1989 from Faculty of Medicine Ain Shams University, Cairo Egypt. · FRCP/Royal College of Physicians and Surgeons /Glasgow August 30th 2019 · He worked in Ibnalkuff Spinal Cord Injuries Rehabilitation Hospital /Baghdad 1984-2005 · (At first HO, SHO, Specialist, Consultant, and Head of Rehab.Dept. Director General 2003-2005. · Supervised Postgraduate Med.Rehab.Training Program 1991-2005(College of Medicine /University of Baghdad). · Patent On An Invention 1998 (Trans Rectal Electro Ejaculator) · Participated in a lot of Local, Regional, Pan Arabs & International Conferences (Speaker, Chairman, attendance) &Published a lot of papers in peer Int. Medical journals. · In 2005 he left Iraq to UAE where he worked as CEO , Chairperson of JCI Accreditation, & Specialist Physician in Physical Medicine Rheumatology & Rehabilitation(October 2005-October 2019) Currently · Working in Prime Hospital /Dubai as part time. · In addition have own Private Clinic (Rheumatology, Medical Rehabilitation & Physiotherapy Clinic in Al-Moosa Clinics & Day Surgery Medical Center /Dubai UAE.

Abstract:

Platelet-rich plasma (PRP) is one of many new developments within the expanding field of regenerative medicine. Specialists in areas such as orthopedics, sport medicine, physical medicine and rehabilitation, and rheumatology have been exploring the benefits of this novel therapy. The use of orthobiologics such as PRP continues to advance as patients seek nonsurgical approaches to acute and chronic musculoskeletal injury and disease. Advancements in this novel bioactive therapy have occurred during the past 2 decades. Recently, the body of literature has grown and we are learning a great deal about the potential for this regenerative therapy. Applications in physiatry, orthopedics, and sports medicine are currently being developed, and regenerative biomedicine is rapidly becoming an exciting and promising treatment option in musculoskeletal medicine. However, much remains to be learned in this emerging field. In this article we will focus on PRP, a bioactive regenerative therapy that has garnered significant attention in recent years. Human clinical trials are emerging that demonstrate the promise of this innovative therapy, which likely will play a major role in shaping the landscape of sports medicine.

Biography:

Abstract:

Background: It's well known that higher BMI scores are protective for osteoporosis in postmenopausal women. Several studies have evaluated the relationship between Bone Mineral Density (BMD) and Body Mass Index (BMI) in patients affected by osteoporosis in different parts of world but few data are present among Italian population. Objectives: Primary aim of this study was to obtain data about BMI and bone mineral levels in the lumbar spine of Italy adult females based on a nationally representative sample of more than 15000 women aged 20 years and older and so to determine the relationship between BMI and BMD. Data were retrospectively extracted from the Magenta's Rheumatology Unit Densitometry Registry Methods: Demographic (age, age at menarche and menopause) and anthropometric (BMI) data of females aged 20 years and older that performed their first DEXA in our Hospital between 2006 and 2014 were extracted from our local registry using a random sampling technique. Bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry (DXA) on a Hologic bone densitometer (QDR 9000 Hologic, Waltham, Mass.). Subjects performed the DEXA scan for screening for osteopenia or because of their increased awareness of their health. Criteria for patient selection were: absence of known risk factors of Osteoporosis (eg smoke, alcohol, metabolic disease that affects bone, fractures), a concomitant or previous treatment of osteoporosis or corticosteroids. Patients with low or high BMI (over 95 percentile) were eligible. Osteopenia and osteoporosis were defined by T-score< -1 and < -2.5, respectively. In this study we used the WHO BMI classification: underweight <18.5 kg/m2; normal weight 18.5-24.9 kg/m2; over weight 25-29.9 kg/m2; obese>30 kg/m2 Results: 15335 DEXA scan analysed. Mean age was 64.2±12.8 years (range 20.8 to 90). 14138 patients were post menopausal. Mean BMI was 26.4±5.1 (range 15 to 36). Mean menopause age was 48.3±5 (range 31-54). Mean menarche age was 16.3±5 (range 11-17). The prevalence of osteoporosis and osteopenia in post menopausal women were 34,3% and 43,9% respectively. In post menopausal subjects we found a positive correlation between BMD and the other variables collected BMI and age at menopause (0.271 and 0.114 respectively, p<0.001). An ANOVA univariate confirmed the direct relationship between BMD and BMI for every value of BMI. In the pre menopausal women we found a relationship with a inverted U-shape. In this subpopulation the lowest and highest BMI values were associated to the lowest BMD values Conclusions: Our study shown a different role of BMI on BMD values: in post menopausal women the BMD seems to have a direct relationship with BMI for every BMI value. On the other hand there is a trend like a parabolic curve, with lower BMD at BMI levels of underweight or overweight, in the premenopausal women.

Biography:

Abstract:

OBJECTIVES: To assess biomechanically different fixations means of the sacroiliac joint with pedicle screws and to compare the traditional head height with reduced ones. METHODS: We used a polyethylene model representing the pelvic ring and simulated a unilateral sacroiliac dislocation. We set up three different constructions: 1) two screws attached to a rod; 2) two rods connected to two small head screws each; and 3) two rods connected to two average headed screws each. We conducted tests in a biomechanical testing and a mechanized processing laboratory. RESULTS: Group 1 supported an average maximum load of 99.70 N. Group 2 supported an average maximum load of 362.46 N. Group 3 endured an average maximum load of 404.15 N. In the assembly with one rod, the resistance decreased as compared with the one with two bars: 72.5 % compared to small-headed screws and 75.3 % to the traditional screw. CONCLUSION: The assembly with a single bar presented inferior results when compared to the double bar assembly. There was no statistical difference in the results between the screws used. Experimental Study.